Safinamide prevents lipopolysaccharide (LPS)-induced inflammation in macrophages by suppressing TLR4/NF-&#954;B signaling.

Qian, LuLu; Li, Jun-Zhao; Sun, XueMei; Chen, Jie-Bin; Dai, Ying; Huang, Qiu-Xiang; Jin, Ying-Ji; Duan, Qing-Ning

Safinamide prevents lipopolysaccharide (LPS)-induced inflammation in macrophages by suppressing TLR4/NF-κB signaling.

Qian, LuLu; Li, Jun-Zhao; Sun, XueMei; Chen, Jie-Bin; Dai, Ying; Huang, Qiu-Xiang; Jin, Ying-Ji; Duan, Qing-Ning.

Affiliation

Qian L; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Li JZ; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Sun X; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Chen JB; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Dai Y; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Huang QX; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Jin YJ; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China.
Duan QN; Department of Pediatrics, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China. Electronic address: wangnan7223@163.com.

Int Immunopharmacol ; 96: 107712, 2021 Jul.

Article in En | MEDLINE | ID: mdl-34162132

Subject(s)

Alanine/analogs & derivatives; Anti-Inflammatory Agents/pharmacology; Benzylamines/pharmacology; Inflammation/prevention & control; Macrophages/drug effects; NF-kappa B/antagonists & inhibitors; Signal Transduction/drug effects; Toll-Like Receptor 4/antagonists & inhibitors; Alanine/pharmacology; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Cytokines/metabolism; Dinoprostone/metabolism; Humans; Inflammation/chemically induced; Inflammation Mediators/metabolism; Lipopolysaccharides/toxicity; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase Type II/genetics; Nitric Oxide Synthase Type II/metabolism; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism; U937 Cells

Key words

Chemokine; Cytokine; Inflammation; LPS; NF-κB; Safinamide; TLR4

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylamines / Signal Transduction / NF-kappa B / Alanine / Toll-Like Receptor 4 / Inflammation / Macrophages / Anti-Inflammatory Agents Limits: Humans Language: En Journal: Int Immunopharmacol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Year: 2021 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google