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Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.
Diabasana, Zania; Perotin, Jeanne-Marie; Belgacemi, Randa; Ancel, Julien; Mulette, Pauline; Launois, Claire; Delepine, Gonzague; Dubernard, Xavier; Mérol, Jean-Claude; Ruaux, Christophe; Gosset, Philippe; Maskos, Uwe; Polette, Myriam; Deslée, Gaëtan; Dormoy, Valérian.
Affiliation
  • Diabasana Z; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Perotin JM; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Belgacemi R; Department of Respiratory Diseases, CHU de Reims, Hôpital Maison Blanche, 51092 Reims, France.
  • Ancel J; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Mulette P; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Launois C; Department of Respiratory Diseases, CHU de Reims, Hôpital Maison Blanche, 51092 Reims, France.
  • Delepine G; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Dubernard X; Department of Respiratory Diseases, CHU de Reims, Hôpital Maison Blanche, 51092 Reims, France.
  • Mérol JC; Department of Respiratory Diseases, CHU de Reims, Hôpital Maison Blanche, 51092 Reims, France.
  • Ruaux C; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Gosset P; Department of Thoracic Surgery, CHU de Reims, Hôpital Maison Blanche, 51092 Reims, France.
  • Maskos U; Department of Otorhinolaryngology, CHU de Reims, Hôpital Robert Debré, 51092 Reims, France.
  • Polette M; Inserm UMR-S1250, P3Cell, University of Reims Champagne-Ardenne, SFR CAP-SANTE, 51092 Reims, France.
  • Deslée G; Department of Otorhinolaryngology, CHU de Reims, Hôpital Robert Debré, 51092 Reims, France.
  • Dormoy V; Department of Otorhinolaryngology, Clinique Mutualiste La Sagesse, 35043 Rennes, France.
Int J Mol Sci ; 22(13)2021 Jun 22.
Article in En | MEDLINE | ID: mdl-34206324
The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell cultures, in situ hybridisation, transcriptomic and cytokines detection, we analysed rs16969968 contribution to respiratory airway epithelial remodelling and modulation of inflammation. We provide cellular and molecular analyses which support the genetic association of this polymorphism with impaired ciliogenesis and the altered production of inflammatory mediators. This suggests its role in lung disease development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Gene Expression Regulation / Receptors, Nicotinic / Respiratory Mucosa / Polymorphism, Single Nucleotide / Inflammation / Nerve Tissue Proteins Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Gene Expression Regulation / Receptors, Nicotinic / Respiratory Mucosa / Polymorphism, Single Nucleotide / Inflammation / Nerve Tissue Proteins Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: France