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Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor.
Gastaldi, Simone; Boscaro, Valentina; Gianquinto, Eleonora; Sandall, Christina F; Giorgis, Marta; Marini, Elisabetta; Blua, Federica; Gallicchio, Margherita; Spyrakis, Francesca; MacDonald, Justin A; Bertinaria, Massimo.
Affiliation
  • Gastaldi S; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Boscaro V; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Gianquinto E; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Sandall CF; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.
  • Giorgis M; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Marini E; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Blua F; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Gallicchio M; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • Spyrakis F; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
  • MacDonald JA; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.
  • Bertinaria M; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy.
Molecules ; 26(13)2021 Jun 29.
Article in En | MEDLINE | ID: mdl-34209843
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-1beta / Pyroptosis / NLR Family, Pyrin Domain-Containing 3 Protein / Imidazoles / Macrophages Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-1beta / Pyroptosis / NLR Family, Pyrin Domain-Containing 3 Protein / Imidazoles / Macrophages Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Italy