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Antinociceptive C19-diterpenoid alkaloids from the root of Aconitum episcopale.
Hu, Jiang; Li, Jia-Xun; Li, Qiang; Mao, Xia; Peng, Tian-Feng; Liu, Hui-Qing; Yin, Si; Yuan, Hong-Jie.
Affiliation
  • Hu J; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Li JX; Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
  • Li Q; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Mao X; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Peng TF; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Liu HQ; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Yin S; College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
  • Yuan HJ; Department of Outpatient, General Hospital of Northern Theater Command, Shenyang 110000, China.
J Asian Nat Prod Res ; 24(7): 617-623, 2022 Jul.
Article in En | MEDLINE | ID: mdl-34304653
ABSTRACT
A chemical investigation on the roots of Aconitum episcopale afforded three undescribed aconitine-type C19-diterpenoid alkaloids, episcopalines A-C (1-3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for their antinociceptive properties. As a result, episcopaline B (2) showed potent antinociceptive effect and its ID50 value (55.0 µmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aconitum / Diterpenes / Alkaloids Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aconitum / Diterpenes / Alkaloids Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2022 Type: Article Affiliation country: China