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Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.
Zhou, Yu-Bo; Zhang, Yang-Ming; Huang, Hong-Hui; Shen, Li-Jing; Han, Xiao-Feng; Hu, Xiao-Bei; Yu, Song-da; Gao, An-Hui; Sheng, Li; Su, Ming-Bo; Wei, Xiao-Li; Zhang, Yue; Zhang, Yi-Fan; Gao, Zhi-Wei; Chen, Xiao-Yan; Nan, Fa-Jun; Li, Jia; Hou, Jian.
Affiliation
  • Zhou YB; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhang YM; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Huang HH; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Shen LJ; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Han XF; Yantai Key Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, Yantai, 264000, China.
  • Hu XB; Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
  • Yu SD; Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
  • Gao AH; Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
  • Sheng L; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Su MB; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Wei XL; Shanghai Center for Drug Metabolism and Pharmacokinetics Research, Shanghai, 201203, China.
  • Zhang Y; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhang YF; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Gao ZW; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Chen XY; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Nan FJ; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Li J; National Center for New Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Hou J; Shanghai Center for Drug Metabolism and Pharmacokinetics Research, Shanghai, 201203, China.
Acta Pharmacol Sin ; 43(4): 1091-1099, 2022 Apr.
Article in En | MEDLINE | ID: mdl-34341512
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Deacetylase Inhibitors / Multiple Myeloma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2022 Type: Article Affiliation country: China
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histone Deacetylase Inhibitors / Multiple Myeloma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2022 Type: Article Affiliation country: China