Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity.

Guan, Liping; Peng, Dingxin; Zhang, Li; Jia, Jinjing; Jiang, Haiying

Guan, Liping; Peng, Dingxin; Zhang, Li; Jia, Jinjing; Jiang, Haiying.

Affiliation

Guan L; Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan 316022, China.
Peng D; Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan 316022, China.
Zhang L; Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan 316022, China.
Jia J; Department of Physiology and Pathophysiology, Jiaxing University Medical College, Jiaxing 314001, China.
Jiang H; Department of Physiology and Pathophysiology, Jiaxing University Medical College, Jiaxing 314001, China. Electronic address: jiangyang7689@aliyun.com.

Bioorg Med Chem Lett ; 52: 128306, 2021 11 15.

Article in En | MEDLINE | ID: mdl-34371131

Subject(s)

Acetylcholinesterase/metabolism; Alzheimer Disease/drug therapy; Butyrylcholinesterase/metabolism; Cholinesterase Inhibitors/pharmacology; Drug Design; Neuroprotective Agents/pharmacology; Alzheimer Disease/metabolism; Cell Line; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/chemistry; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents/chemical synthesis; Neuroprotective Agents/chemistry; Structure-Activity Relationship

Key words

Acetylcholinesterase; Alzheimer's disease; Antioxidant; Butyrylcholinesterase; Liquiritigenin; Synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Butyrylcholinesterase / Drug Design / Cholinesterase Inhibitors / Neuroprotective Agents / Alzheimer Disease Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article Affiliation country: China

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