BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-&#954;B in NSCLC.

Shi, Liu; Xiong, Yu; Hu, Xiaoyan; Wang, Zhihao; Xie, Conghua

BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC.

Shi, Liu; Xiong, Yu; Hu, Xiaoyan; Wang, Zhihao; Xie, Conghua.

Affiliation

Shi L; Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiong Y; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan, China.
Hu X; Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wang Z; Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xie C; Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan, China.

Int J Med Sci ; 18(14): 3090-3096, 2021.

Article in En | MEDLINE | ID: mdl-34400879

Subject(s)

Azepines/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Cell Cycle Proteins/antagonists & inhibitors; Lung Neoplasms/drug therapy; TNF-Related Apoptosis-Inducing Ligand/administration & dosage; Transcription Factors/antagonists & inhibitors; Triazoles/pharmacology; A549 Cells; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Apoptosis/drug effects; Apoptosis/genetics; Azepines/therapeutic use; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/pathology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Fas-Associated Death Domain Protein/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Gene Knockdown Techniques; Humans; Lung Neoplasms/genetics; Lung Neoplasms/pathology; NF-kappa B/metabolism; Recombinant Proteins/administration & dosage; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation/drug effects; Triazoles/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Transcription Factors / Triazoles / Carcinoma, Non-Small-Cell Lung / Cell Cycle Proteins / TNF-Related Apoptosis-Inducing Ligand / Lung Neoplasms Limits: Humans Language: En Journal: Int J Med Sci Journal subject: MEDICINA Year: 2021 Type: Article Affiliation country: China

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