A human apolipoprotein L with detergent-like activity kills intracellular pathogens.

Gaudet, Ryan G; Zhu, Shiwei; Halder, Anushka; Kim, Bae-Hoon; Bradfield, Clinton J; Huang, Shuai; Xu, Dijin; Mamiñska, Agnieszka; Nguyen, Thanh Ngoc; Lazarou, Michael; Karatekin, Erdem; Gupta, Kallol; MacMicking, John D

Gaudet, Ryan G; Zhu, Shiwei; Halder, Anushka; Kim, Bae-Hoon; Bradfield, Clinton J; Huang, Shuai; Xu, Dijin; Mamiñska, Agnieszka; Nguyen, Thanh Ngoc; Lazarou, Michael; Karatekin, Erdem; Gupta, Kallol; MacMicking, John D.

Affiliation

Gaudet RG; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
Zhu S; Yale Systems Biology Institute, West Haven, CT 06477, USA.
Halder A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Kim BH; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Bradfield CJ; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
Huang S; Yale Systems Biology Institute, West Haven, CT 06477, USA.
Xu D; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Mamiñska A; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Nguyen TN; Yale Nanobiology Institute, West Haven, CT 06477, USA.
Lazarou M; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.
Karatekin E; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
Gupta K; Yale Systems Biology Institute, West Haven, CT 06477, USA.
MacMicking JD; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Science ; 373(6552)2021 07 16.

Article in En | MEDLINE | ID: mdl-34437126

Subject(s)

Apolipoproteins L/metabolism; Cell Membrane/metabolism; Cytosol/microbiology; Gram-Negative Bacteria/physiology; Interferon-gamma/immunology; Apolipoproteins L/chemistry; Apolipoproteins L/genetics; Bacterial Outer Membrane/metabolism; Bacteriolysis; CRISPR-Cas Systems; Cell Membrane/chemistry; Cell Membrane/ultrastructure; Cell Membrane Permeability; Cells, Cultured; Detergents/metabolism; GTP-Binding Proteins/metabolism; Gene Editing; Gram-Negative Bacteria/immunology; Gram-Negative Bacteria/pathogenicity; Gram-Negative Bacteria/ultrastructure; Humans; Immunity, Innate; Lipoproteins/chemistry; Microbial Viability; O Antigens/metabolism; Protein Domains; Salmonella typhimurium/immunology; Salmonella typhimurium/pathogenicity; Salmonella typhimurium/physiology; Salmonella typhimurium/ultrastructure; Solubility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Membrane / Interferon-gamma / Cytosol / Apolipoproteins L / Gram-Negative Bacteria Limits: Humans Language: En Journal: Science Year: 2021 Type: Article Affiliation country: United States

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