New potential antiproliferative monophosphoester 2-aminoethyl dihydrogen phosphate in K-562 and K-562 MDR<sup>+</sup> leukemia cells.

Conceição, T O; Cabral, Lgs; Laveli-Silva, M G; Pacheco, J C; Alves, M G; Rabelo, D C; Laiso, Ran; Maria, D A

New potential antiproliferative monophosphoester 2-aminoethyl dihydrogen phosphate in K-562 and K-562 MDR⁺ leukemia cells.

Conceição, T O; Cabral, Lgs; Laveli-Silva, M G; Pacheco, J C; Alves, M G; Rabelo, D C; Laiso, Ran; Maria, D A.

Affiliation

Conceição TO; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil. Electronic address: thais.conceicao@fm.usp.br.
Cabral L; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil. Electronic address: laertty.c@usp.br.
Laveli-Silva MG; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil.
Pacheco JC; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil.
Alves MG; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil.
Rabelo DC; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil.
Laiso R; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil.
Maria DA; Faculty of Medicine, University of Sao Paulo, FMUSP, Sao Paulo, SP, Brazil; Laboratory of Development and Innovation, Butantan Institute, Sao Paulo, SP, Brazil. Electronic address: durvanei@usp.br.

Biomed Pharmacother ; 142: 112054, 2021 Oct.

Article in En | MEDLINE | ID: mdl-34463267

Subject(s)

Antineoplastic Agents/pharmacology; Cell Proliferation/drug effects; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Organophosphates/pharmacology; Apoptosis/drug effects; Apoptosis Regulatory Proteins/metabolism; Cell Cycle/drug effects; Cell Death/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Drug Resistance, Multiple/drug effects; Drug Synergism; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Liposomes/chemistry; Liposomes/pharmacology; Membrane Potential, Mitochondrial/drug effects; Oleic Acids/chemistry; Oleic Acids/pharmacology; Quaternary Ammonium Compounds/chemistry; Quaternary Ammonium Compounds/pharmacology

Key words

2-AEH(2)P; DODAC carrier; Drug resistance; Leukemia; Liposomal formulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphates / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Cell Proliferation / Antineoplastic Agents Limits: Humans Language: En Journal: Biomed Pharmacother Year: 2021 Type: Article

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