Your browser doesn't support javascript.
loading
Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques.
King, Hannah A D; Joyce, M Gordon; Lakhal-Naouar, Ines; Ahmed, Aslaa; Cincotta, Camila Macedo; Subra, Caroline; Peachman, Kristina K; Hack, Holly R; Chen, Rita E; Thomas, Paul V; Chen, Wei-Hung; Sankhala, Rajeshwer S; Hajduczki, Agnes; Martinez, Elizabeth J; Peterson, Caroline E; Chang, William C; Choe, Misook; Smith, Clayton; Headley, Jarrett A; Elyard, Hanne A; Cook, Anthony; Anderson, Alexander; Wuertz, Kathryn McGuckin; Dong, Ming; Swafford, Isabella; Case, James B; Currier, Jeffrey R; Lal, Kerri G; Amare, Mihret F; Dussupt, Vincent; Molnar, Sebastian; Daye, Sharon P; Zeng, Xiankun; Barkei, Erica K; Alfson, Kendra; Staples, Hilary M; Carrion, Ricardo; Krebs, Shelly J; Paquin-Proulx, Dominic; Karasavvas, Nicos; Polonis, Victoria R; Jagodzinski, Linda L; Vasan, Sandhya; Scott, Paul T; Huang, Yaoxing; Nair, Manoj S; Ho, David D; de Val, Natalia; Diamond, Michael S; Lewis, Mark G.
Affiliation
  • King HAD; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Joyce MG; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Lakhal-Naouar I; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Ahmed A; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Cincotta CM; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Subra C; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Peachman KK; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Hack HR; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Chen RE; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Thomas PV; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Chen WH; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Sankhala RS; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Hajduczki A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Martinez EJ; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Peterson CE; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Chang WC; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Choe M; Department of Medicine, Washington University, St. Louis, MO 63130.
  • Smith C; Department of Pathology & Immunology, Washington University, St. Louis, MO 63130.
  • Headley JA; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Elyard HA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Cook A; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Anderson A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Wuertz KM; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Dong M; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Swafford I; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Case JB; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Currier JR; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Lal KG; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Amare MF; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Dussupt V; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Molnar S; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Daye SP; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Zeng X; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Barkei EK; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Alfson K; Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD 21702.
  • Staples HM; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Carrion R; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Krebs SJ; BIOQUAL, Inc., Rockville, MD 20850.
  • Paquin-Proulx D; BIOQUAL, Inc., Rockville, MD 20850.
  • Karasavvas N; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Polonis VR; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Jagodzinski LL; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Vasan S; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Scott PT; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Huang Y; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Nair MS; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Ho DD; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • de Val N; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
  • Diamond MS; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817.
  • Lewis MG; Department of Medicine, Washington University, St. Louis, MO 63130.
Proc Natl Acad Sci U S A ; 118(38)2021 09 21.
Article in En | MEDLINE | ID: mdl-34470866
Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vaccination of macaques using a two-dose regimen resulted in robust, predominantly Th1 CD4+ T cell responses and reciprocal peak mean serum neutralizing antibody titers of 14,000 to 21,000. Rapid control of viral replication was achieved in the upper and lower airways of animals after high-dose SARS-CoV-2 respiratory challenge, with undetectable replication within 4 d in seven of eight animals receiving 50 µg of RFN. Cross-neutralization activity against SARS-CoV-2 variant B.1.351 decreased only approximately twofold relative to WA1/2020. In addition, neutralizing, effector antibody and cellular responses targeted the heterotypic SARS-CoV-1, highlighting the broad immunogenicity of RFN-ALFQ for SARS-CoV-like Sarbecovirus vaccine development.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Virus / Nanoparticles / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Macaca mulatta Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Virus / Nanoparticles / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Macaca mulatta Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article