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Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report.
Davies, Cathy; Appiah-Kusi, Elizabeth; Wilson, Robin; Blest-Hopley, Grace; Bossong, Matthijs G; Valmaggia, Lucia; Brammer, Michael; Perez, Jesus; Allen, Paul; Murray, Robin M; McGuire, Philip; Bhattacharyya, Sagnik.
Affiliation
  • Davies C; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
  • Appiah-Kusi E; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
  • Wilson R; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
  • Blest-Hopley G; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
  • Bossong MG; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
  • Valmaggia L; Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Brammer M; National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK.
  • Perez J; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Allen P; CAMEO Early Intervention Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
  • Murray RM; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
  • McGuire P; Department of Psychology, University of Roehampton, London, UK.
  • Bhattacharyya S; Icahn School of Medicine, Mount Sinai Hospital, New York, USA.
Eur Arch Psychiatry Clin Neurosci ; 272(3): 461-475, 2022 Apr.
Article in En | MEDLINE | ID: mdl-34480630
Evidence suggests that people at Clinical High Risk for Psychosis (CHR) have a blunted cortisol response to stress and altered mediotemporal activation during fear processing, which may be neuroendocrine-neuronal signatures of maladaptive threat responses. However, whether these facets are associated with each other and how this relationship is affected by cannabidiol treatment is unknown. We examined the relationship between cortisol response to social stress and mediotemporal function during fear processing in healthy people and in CHR patients. In exploratory analyses, we investigated whether treatment with cannabidiol in CHR individuals could normalise any putative alterations in cortisol-mediotemporal coupling. 33 CHR patients were randomised to 600 mg cannabidiol or placebo treatment. Healthy controls (n = 19) did not receive any drug. Mediotemporal function was assessed using a fearful face-processing functional magnetic resonance imaging paradigm. Serum cortisol and anxiety were measured immediately following the Trier Social Stress Test. The relationship between cortisol and mediotemporal blood-oxygen-level-dependent haemodynamic response was investigated using linear regression. In healthy controls, there was a significant negative relationship between cortisol and parahippocampal activation (p = 0.023), such that the higher the cortisol levels induced by social stress, the lower the parahippocampal activation (greater deactivation) during fear processing. This relationship differed significantly between the control and placebo groups (p = 0.033), but not between the placebo and cannabidiol groups (p = 0.67). Our preliminary findings suggest that the parahippocampal response to fear processing may be associated with the neuroendocrine (cortisol) response to experimentally induced social stress, and that this relationship may be altered in patients at clinical high risk for psychosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psychotic Disorders / Cannabidiol Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur Arch Psychiatry Clin Neurosci Journal subject: NEUROLOGIA / PSIQUIATRIA Year: 2022 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psychotic Disorders / Cannabidiol Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Eur Arch Psychiatry Clin Neurosci Journal subject: NEUROLOGIA / PSIQUIATRIA Year: 2022 Type: Article