Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways.

Wei, Ling; Wen, Xue-Sen; Xian, Cory J

Wei, Ling; Wen, Xue-Sen; Xian, Cory J.

Affiliation

Wei L; School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Wen XS; School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Xian CJ; UniSA Clinical & Health Science, City West Campus, University of South Australia, Adelaide, SA 5001, Australia.

Int J Mol Sci ; 22(17)2021 Aug 31.

Article in En | MEDLINE | ID: mdl-34502383

Subject(s)

Drug-Related Side Effects and Adverse Reactions/microbiology; Gastrointestinal Microbiome/drug effects; Intestinal Mucosa/microbiology; Animals; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Drug Therapy/methods; Drug-Related Side Effects and Adverse Reactions/physiopathology; Dysbiosis/microbiology; Dysbiosis/physiopathology; Fluorouracil/pharmacology; Gastrointestinal Microbiome/physiology; Homeostasis; Humans; Intestines/microbiology; Microbiota/drug effects; Mucositis/chemically induced; Quality of Life; Signal Transduction/drug effects; Toll-Like Receptors/metabolism; Toll-Like Receptors/physiology

Key words

chemotherapy; intestinal microbiota dysbiosis; mucositis; toll-like receptors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions / Gastrointestinal Microbiome / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: China

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