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NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway.
Zhao, Yao; Zhang, Jiawei; Zheng, Yaling; Zhang, Yaxuan; Zhang, Xiao Jie; Wang, Hongmei; Du, Yu; Guan, Jian; Wang, Xiuzhe; Fu, Jianliang.
Affiliation
  • Zhao Y; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Zhang J; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Zheng Y; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Zhang Y; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Zhang XJ; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Wang H; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Du Y; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
  • Guan J; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
  • Wang X; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China. xiuzhewang@hotmail.com.
  • Fu J; Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China. fujianliang@163.com.
J Neuroinflammation ; 18(1): 207, 2021 Sep 16.
Article in En | MEDLINE | ID: mdl-34530866
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Sirtuin 1 / Cognitive Dysfunction / Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Neuroinflammatory Diseases / Mitochondria / NAD Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Sirtuin 1 / Cognitive Dysfunction / Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Neuroinflammatory Diseases / Mitochondria / NAD Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2021 Type: Article Affiliation country: China