Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5.
Somat Cell Mol Genet
; 12(1): 89-94, 1986 Jan.
Article
in En
| MEDLINE
| ID: mdl-3456176
ABSTRACT
We have used hamster cDNA probes for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR) to determine the chromosomal location of the human gene for HMG CoA reductase. Southern blot analysis of genomic DNA from 16 independent mouse-human somatic cell hybrids showed that the human gene for HMG CoA reductase resides on chromosome 5. Analysis of Chinese hamster-human somatic cell hybrids selectively retaining human 5 or a portion of it showed that the gene locus for HMG CoA reductase can be assigned to the q13----q23 region of chromosome 5.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosome Mapping
/
Chromosomes, Human, 4-5
/
Genes
/
Hydroxymethylglutaryl CoA Reductases
Limits:
Animals
/
Humans
Language:
En
Journal:
Somat Cell Mol Genet
Year:
1986
Type:
Article