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The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).
Ngandu, Tiia; Lehtisalo, Jenni; Korkki, Saana; Solomon, Alina; Coley, Nicola; Antikainen, Riitta; Bäckman, Lars; Hänninen, Tuomo; Lindström, Jaana; Laatikainen, Tiina; Paajanen, Teemu; Havulinna, Satu; Peltonen, Markku; Neely, Anna Stigsdotter; Strandberg, Timo; Tuomilehto, Jaakko; Soininen, Hilkka; Kivipelto, Miia.
Affiliation
  • Ngandu T; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Lehtisalo J; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.
  • Korkki S; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Solomon A; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
  • Coley N; Department of Psychology, University of Cambridge, Cambridge, UK.
  • Antikainen R; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
  • Bäckman L; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.
  • Hänninen T; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
  • Lindström J; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.
  • Laatikainen T; Faculté de Médecine, INSERM-University of Toulouse UMR1295 (CERPOP), Toulouse, France.
  • Paajanen T; Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France.
  • Havulinna S; Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Peltonen M; Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
  • Neely AS; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
  • Strandberg T; Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
  • Tuomilehto J; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Soininen H; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Kivipelto M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Alzheimers Dement ; 18(7): 1325-1334, 2022 07.
Article in En | MEDLINE | ID: mdl-34668644
ABSTRACT

INTRODUCTION:

Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses).

METHODS:

FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.

RESULTS:

Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.

DISCUSSION:

Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognition Disorders / Cognitive Dysfunction Type of study: Clinical_trials Limits: Humans Language: En Journal: Alzheimers Dement Year: 2022 Type: Article Affiliation country: Finland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognition Disorders / Cognitive Dysfunction Type of study: Clinical_trials Limits: Humans Language: En Journal: Alzheimers Dement Year: 2022 Type: Article Affiliation country: Finland