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Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties.
Hempel, Tim; Elez, Katarina; Krüger, Nadine; Raich, Lluís; Shrimp, Jonathan H; Danov, Olga; Jonigk, Danny; Braun, Armin; Shen, Min; Hall, Matthew D; Pöhlmann, Stefan; Hoffmann, Markus; Noé, Frank.
Affiliation
  • Hempel T; Department of Mathematics and Computer Science, Freie Universität Berlin Berlin Germany frank.noe@fu-berlin.de.
  • Elez K; Department of Physics, Freie Universität Berlin Berlin Germany.
  • Krüger N; Department of Mathematics and Computer Science, Freie Universität Berlin Berlin Germany frank.noe@fu-berlin.de.
  • Raich L; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research Göttingen Germany.
  • Shrimp JH; Department of Mathematics and Computer Science, Freie Universität Berlin Berlin Germany frank.noe@fu-berlin.de.
  • Danov O; National Center for Advancing Translational Sciences, National Institutes of Health Rockville MD USA.
  • Jonigk D; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR) Hannover German
  • Braun A; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR) Hannover German
  • Shen M; Institute of Pathology, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Hannover Germany.
  • Hall MD; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR) Hannover German
  • Pöhlmann S; National Center for Advancing Translational Sciences, National Institutes of Health Rockville MD USA.
  • Hoffmann M; National Center for Advancing Translational Sciences, National Institutes of Health Rockville MD USA.
  • Noé F; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research Göttingen Germany.
Chem Sci ; 12(38): 12600-12609, 2021 Oct 06.
Article in En | MEDLINE | ID: mdl-34703545
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2021 Type: Article