A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.
Chem Commun (Camb)
; 58(5): 645-648, 2022 Jan 13.
Article
in En
| MEDLINE
| ID: mdl-34747956
ABSTRACT
Herein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this in the on-resin synthesis of biologically relevant oxytocin. Furthermore, we establish the applicability of the PD protecting group towards both microwave-assisted SPPS and native chemical ligation (NCL) in a model system.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Solid-Phase Synthesis Techniques
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2022
Type:
Article
Affiliation country:
United kingdom