Using existing knowledge for the risk evaluation of crop protection products in order to guide exposure driven data generation strategies and minimise unnecessary animal testing.

Parsons, Paul; Freeman, Elaine; Weidling, Ryan; Williams, Gary L; Gill, Philip; Byron, Neil

Parsons, Paul; Freeman, Elaine; Weidling, Ryan; Williams, Gary L; Gill, Philip; Byron, Neil.

Affiliation

Parsons P; Exponent® International Limited, Harrogate, UK.
Freeman E; Exponent Inc, Washington DC, USA.
Weidling R; Exponent Inc, Washington DC, USA.
Williams GL; Exponent® International Limited, Harrogate, UK.
Gill P; Exponent® International Limited, Harrogate, UK.
Byron N; Exponent® International Limited, Harrogate, UK.

Crit Rev Toxicol ; 51(7): 600-621, 2021 08.

Article in En | MEDLINE | ID: mdl-34756157

Subject(s)

Crop Protection; Occupational Exposure; Animals; Humans; Risk Assessment

Key words

Exposure prediction; acceptability of risk; exposure driven testing strategy; human health risk assessment; reduction in animal use; reference dose derivation; study waivers

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Occupational Exposure / Crop Protection Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Crit Rev Toxicol Journal subject: TOXICOLOGIA Year: 2021 Type: Article Affiliation country: United kingdom

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