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Stepwise synaptic plasticity events drive the early phase of memory consolidation.
Goto, Akihiro; Bota, Ayaka; Miya, Ken; Wang, Jingbo; Tsukamoto, Suzune; Jiang, Xinzhi; Hirai, Daichi; Murayama, Masanori; Matsuda, Tomoki; McHugh, Thomas J; Nagai, Takeharu; Hayashi, Yasunori.
Affiliation
  • Goto A; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
  • Bota A; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
  • Miya K; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
  • Wang J; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
  • Tsukamoto S; Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
  • Jiang X; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
  • Hirai D; Department of Molecular Neurobiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
  • Murayama M; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
  • Matsuda T; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
  • McHugh TJ; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
  • Nagai T; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
  • Hayashi Y; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
Science ; 374(6569): 857-863, 2021 Nov 12.
Article in En | MEDLINE | ID: mdl-34762472
Memories are initially encoded in the hippocampus but subsequently consolidated to the cortex. Although synaptic plasticity is key to these processes, its precise spatiotemporal profile remains poorly understood. Using optogenetics to selectively erase long-term potentiation (LTP) within a defined temporal window, we found that distinct phases of synaptic plasticity play differential roles. The first wave acts locally in the hippocampus to confer context specificity. The second wave, during sleep on the same day, organizes these neurons into synchronously firing assemblies. Finally, LTP in the anterior cingulate cortex during sleep on the second day is required for further stabilization of the memory. This demonstrates the precise localization, timing, and characteristic contributions of the plasticity events that underlie the early phase of memory consolidation.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CA1 Region, Hippocampal / Memory Consolidation / Neuronal Plasticity Limits: Animals Language: En Journal: Science Year: 2021 Type: Article Affiliation country: Japan

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CA1 Region, Hippocampal / Memory Consolidation / Neuronal Plasticity Limits: Animals Language: En Journal: Science Year: 2021 Type: Article Affiliation country: Japan