Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor.
N Engl J Med
; 385(21): 1974-1980, 2021 11 18.
Article
in En
| MEDLINE
| ID: mdl-34788508
ABSTRACT
We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which block PTH binding and signaling. Both cases were associated with other autoimmune manifestations, and one case was associated with atypical membranous glomerulonephritis. In vitro binding and signaling assays identified the presence of PTH1R-blocking IgG autoantibodies, which were not present in serum samples from patients with other renal or autoimmune disorders. (Funded by the Intramural Research Programs of the National Institute of Diabetes and Digestive and Kidney Diseases and others.).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parathyroid Hormone
/
Autoantibodies
/
Receptor, Parathyroid Hormone, Type 1
/
Hypocalcemia
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
En
Journal:
N Engl J Med
Year:
2021
Type:
Article
Affiliation country:
Netherlands Antilles