Structural modification and antihypertensive activity study of formononetin derivatives.
J Asian Nat Prod Res
; 24(9): 839-848, 2022 Sep.
Article
in En
| MEDLINE
| ID: mdl-34844472
ABSTRACT
A series of formononetin derivatives with substituted benzyloxy groups on the 4' position of isoflavone were designed and synthesized. Their vasodilative activities were evaluated by wire myograph system on isolated rat mesenteric arterial ring. The preliminary SAR of target compounds was thus discussed. Compounds 3d and 3e exhibited potent vasodilative activities against the rat mesenteric arterial rings induced contraction with K+. Compounds 3d and 3e also showed antihypertensive effects in SHRs by oral administration.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Isoflavones
/
Antihypertensive Agents
Limits:
Animals
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2022
Type:
Article
Affiliation country:
China