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CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia.
Zebley, Caitlin C; Brown, Charmaine; Mi, Tian; Fan, Yiping; Alli, Shanta; Boi, Shannon; Galletti, Giovanni; Lugli, Enrico; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Meagher, Michael; Triplett, Brandon; Talleur, Aimee C; Gottschalk, Stephen; Youngblood, Ben.
Affiliation
  • Zebley CC; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: caitlin.zebley@stjude.org.
  • Brown C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Mi T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Fan Y; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Alli S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Boi S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Galletti G; Laboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
  • Lugli E; Laboratory of Translational Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
  • Langfitt D; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Metais JY; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Lockey T; Therapeutics Production and Quality, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Meagher M; Therapeutics Production and Quality, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Triplett B; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Talleur AC; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Gottschalk S; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Youngblood B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: benjamin.youngblood@stjude.org.
Cell Rep ; 37(9): 110079, 2021 11 30.
Article in En | MEDLINE | ID: mdl-34852226
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Gene Expression Regulation, Neoplastic / Immunotherapy, Adoptive / CD8-Positive T-Lymphocytes / Antigens, CD19 / DNA Methylation / Precursor Cell Lymphoblastic Leukemia-Lymphoma Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Cell Rep Year: 2021 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Gene Expression Regulation, Neoplastic / Immunotherapy, Adoptive / CD8-Positive T-Lymphocytes / Antigens, CD19 / DNA Methylation / Precursor Cell Lymphoblastic Leukemia-Lymphoma Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Cell Rep Year: 2021 Type: Article