Mimicking Elementary Reactions of Manganese Lipoxygenase Using Mn-hydroxo and Mn-alkylperoxo Complexes.

Opalade, Adedamola A; Grotemeyer, Elizabeth N; Jackson, Timothy A

Opalade, Adedamola A; Grotemeyer, Elizabeth N; Jackson, Timothy A.

Affiliation

Opalade AA; Department of Chemistry and Center for Environmentally Beneficial Catalysis, The University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.
Grotemeyer EN; Department of Chemistry and Center for Environmentally Beneficial Catalysis, The University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.
Jackson TA; Department of Chemistry and Center for Environmentally Beneficial Catalysis, The University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.

Molecules ; 26(23)2021 Nov 25.

Article in En | MEDLINE | ID: mdl-34885729

Subject(s)

Coordination Complexes/chemistry; Lipid Peroxides/chemistry; Lipoxygenase/chemistry; Manganese/chemistry; Biomimetics; Catalytic Domain/drug effects; Coordination Complexes/pharmacology; Fatty Acids, Unsaturated/chemistry; Fatty Acids, Unsaturated/metabolism; Hydrogen/chemistry; Ligands; Lipid Peroxides/metabolism; Lipoxygenase/drug effects; Molecular Structure; Oxidation-Reduction/drug effects; Oxygen/chemistry; Piperidines/chemistry; Piperidines/pharmacology

Key words

alkylperoxo; hydrogen-atom transfer; ligand substitution; lipoxygenase; manganese enzymes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipoxygenase / Coordination Complexes / Lipid Peroxides / Manganese Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: United States

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