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Broadly neutralizing antibodies target a haemagglutinin anchor epitope.
Guthmiller, Jenna J; Han, Julianna; Utset, Henry A; Li, Lei; Lan, Linda Yu-Ling; Henry, Carole; Stamper, Christopher T; McMahon, Meagan; O'Dell, George; Fernández-Quintero, Monica L; Freyn, Alec W; Amanat, Fatima; Stovicek, Olivia; Gentles, Lauren; Richey, Sara T; de la Peña, Alba Torrents; Rosado, Victoria; Dugan, Haley L; Zheng, Nai-Ying; Tepora, Micah E; Bitar, Dalia J; Changrob, Siriruk; Strohmeier, Shirin; Huang, Min; García-Sastre, Adolfo; Liedl, Klaus R; Bloom, Jesse D; Nachbagauer, Raffael; Palese, Peter; Krammer, Florian; Coughlan, Lynda; Ward, Andrew B; Wilson, Patrick C.
Affiliation
  • Guthmiller JJ; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA. jguthmiller@uchicago.edu.
  • Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Utset HA; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Li L; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Lan LY; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Henry C; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Stamper CT; Moderna Inc., Cambridge, MA, USA.
  • McMahon M; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • O'Dell G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Fernández-Quintero ML; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Freyn AW; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
  • Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Stovicek O; Moderna Inc., Cambridge, MA, USA.
  • Gentles L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Richey ST; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • de la Peña AT; Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Rosado V; Department of Microbiology, University of Washington, Seattle, WA, USA.
  • Dugan HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Zheng NY; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
  • Tepora ME; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bitar DJ; Committee on Immunology, University of Chicago, Chicago, IL, USA.
  • Changrob S; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Strohmeier S; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Huang M; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • García-Sastre A; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Liedl KR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bloom JD; Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
  • Nachbagauer R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Palese P; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Krammer F; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Coughlan L; The Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Ward AB; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Wilson PC; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.
Nature ; 602(7896): 314-320, 2022 02.
Article in En | MEDLINE | ID: mdl-34942633
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemagglutinin Glycoproteins, Influenza Virus / Antibodies, Neutralizing / Broadly Neutralizing Antibodies / Antibodies, Viral / Epitopes Limits: Humans Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemagglutinin Glycoproteins, Influenza Virus / Antibodies, Neutralizing / Broadly Neutralizing Antibodies / Antibodies, Viral / Epitopes Limits: Humans Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: United States