Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway.

Mohamad, Khalid A; El-Naga, Reem N; Wahdan, Sara A

Mohamad, Khalid A; El-Naga, Reem N; Wahdan, Sara A.

Affiliation

Mohamad KA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: khaled.mohamed1@pharma.asu.edu.eg.
El-Naga RN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: reemelnaga@pharma.asu.edu.eg.
Wahdan SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: sara_wahdan@pharma.asu.edu.eg.

Toxicol Appl Pharmacol ; 435: 115853, 2022 01 15.

Article in En | MEDLINE | ID: mdl-34973289

Subject(s)

Indoles/pharmacology; MAP Kinase Signaling System/drug effects; Neuroprotective Agents/pharmacology; Parkinson Disease, Secondary/chemically induced; Parkinson Disease, Secondary/prevention & control; Rotenone; Sirtuin 1/metabolism; Uncoupling Agents; Animals; Body Weight/drug effects; Catalepsy/chemically induced; Catalepsy/prevention & control; Dopamine/metabolism; Male; Motor Activity/drug effects; Neostriatum/drug effects; Neostriatum/metabolism; Parkinson Disease, Secondary/psychology; Postural Balance/drug effects; Rats; Rats, Sprague-Dawley; Sirtuin 1/drug effects; Tyrosine 3-Monooxygenase/metabolism; alpha-Synuclein/biosynthesis; alpha-Synuclein/drug effects

Key words

AMPK; Indole-3-carbinol; Parkinson's disease; Rats; Rotenone; Sirtuin 1 (SIRT1)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease, Secondary / Rotenone / Uncoupling Agents / Neuroprotective Agents / MAP Kinase Signaling System / Sirtuin 1 / Indoles Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2022 Type: Article

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