Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4.
J Exp Med
; 166(4): 1198-203, 1987 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-3498789
ABSTRACT
The lacrimal gland inflammatory lesions and renal vasculitic lesions of autoimmune MRL/lpr mice were analyzed for the lymphocyte subsets present. The majority of cells were Thy-1.2+ T cells (mean, 85%) of the L3T4+ helper T phenotype (mean, 64 and 58%, respectively). Lesser numbers of Lyt-2+ suppressor/cytotoxic T cells, B cells, and macrophages were present. The finding that the majority of lymphocytes in both the lacrimal gland inflammatory lesions and renal vasculitis of MRL/lpr mice expressed L3T4 suggests that these cells may be capable of responding to antigen presentation and that an active immunologic response occurs at these sites.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vasculitis
/
Antigens, Differentiation, T-Lymphocyte
/
Lacrimal Apparatus
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
1987
Type:
Article