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Osmium(VI) nitride triggers mitochondria-induced oncosis and apoptosis.
Ye, Meng; Huang, Wan-Qiong; Li, Zi-Xin; Wang, Chuan-Xian; Liu, Tao; Chen, YunZhou; Hor, Catherine Hong-Huan; Man, Wai-Lun; Ni, Wen-Xiu.
Affiliation
  • Ye M; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China. wxni@stu.edu.cn.
  • Huang WQ; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China. wxni@stu.edu.cn.
  • Li ZX; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China. wxni@stu.edu.cn.
  • Wang CX; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China. wxni@stu.edu.cn.
  • Liu T; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China. wxni@stu.edu.cn.
  • Chen Y; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, HKSAR, P. R. China. wlman118@hkbu.edu.hk.
  • Hor CH; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, HKSAR, P. R. China. wlman118@hkbu.edu.hk.
  • Man WL; Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, HKSAR, P. R. China. wlman118@hkbu.edu.hk.
  • Ni WX; Department of Medicinal Chemistry, Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China. wxni@stu.edu.cn.
Chem Commun (Camb) ; 58(15): 2468-2471, 2022 Feb 17.
Article in En | MEDLINE | ID: mdl-35024704
ABSTRACT
We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osmium / Apoptosis / Coordination Complexes / Mitochondria / Antineoplastic Agents / Nitriles Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osmium / Apoptosis / Coordination Complexes / Mitochondria / Antineoplastic Agents / Nitriles Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Type: Article