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Pembrolizumab-related cholangitis with multiple fatal liver abscesses after endoscopic biliary drainage: a case report and review of the literature.
Hori, Hitomi; Fujita, Koichi; Nishio, Akihiro; Nishijima, Masayoshi; Inaba, Mayumi; Anami, Takahiro; Matsui, Saori; Kitamura, Yasuaki; Matsuoka, Risa; Watanabe, Akihiko.
Affiliation
  • Hori H; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.
  • Fujita K; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan. koichifujitarm@gmail.com.
  • Nishio A; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.
  • Nishijima M; Department of Gastroenterology and Hepatology Medicine, Nisinokyo Hospital, Nara, Japan.
  • Inaba M; Department of Respiratory Medicine, Yodogawa Christian Hospital, Osaka, Japan.
  • Anami T; Department of Pathology, Yodogawa Christian Hospital, Osaka, Japan.
  • Matsui S; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.
  • Kitamura Y; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.
  • Matsuoka R; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.
  • Watanabe A; Department of Gastroenterology and Hepatology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.
Clin J Gastroenterol ; 15(2): 475-479, 2022 Apr.
Article in En | MEDLINE | ID: mdl-35072901
ABSTRACT
A 60-year-old male with cStage IVB lung cancer was treated with pembrolizumab. However, after five courses of pembrolizumab, he developed pembrolizumab-related cholangitis. Imaging studies showed enlargement and diffuse wall thickening of the gallbladder and mild dilation of the bile ducts without any obvious obstruction. As the patient experienced severe abdominal pain, we suspected bile stasis and performed biliary drainage. However, his condition did not improve, and he developed multiple liver abscesses and died during immunosuppressive therapy. Our case suggests that in ir-cholangitis, the indication and method of endoscopic retrograde cholangiopancreatography should be carefully judged.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholangitis, Sclerosing / Cholangitis / Liver Abscess Type of study: Etiology_studies Limits: Humans / Male / Middle aged Language: En Journal: Clin J Gastroenterol Year: 2022 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholangitis, Sclerosing / Cholangitis / Liver Abscess Type of study: Etiology_studies Limits: Humans / Male / Middle aged Language: En Journal: Clin J Gastroenterol Year: 2022 Type: Article Affiliation country: Japan