Racial differences in dysregulation of the renin-angiotensin-aldosterone system in patients with prurigo nodularis.
J Dermatol Sci
; 105(2): 130-136, 2022 Feb.
Article
in En
| MEDLINE
| ID: mdl-35151532
ABSTRACT
BACKGROUND:
There are limited data characterizing the association between renal disease and prurigo nodularis (PN).OBJECTIVE:
To characterize the association and describe mechanistic disease linkages between PN and renal comorbidities.METHODS:
We conducted a cross-sectional analysis of renal comorbidities in PN using TriNetX, a global health research network providing access to medical records. Epidemiological findings provided the basis for translational studies on plasma and skin biopsy samples from PN patients stratified by race.RESULTS:
PN was associated with stages 1-5 of chronic kidney disease (CKD), end-stage renal disease, nephritic syndrome, nephrotic syndrome, glomerular disease, and tubulointerstitial disease, but the associations were significantly stronger in black patients. Compared to controls, CKD progression was faster (HR 2.88, 95% CI 1.01-8.26) only in black PN (10-year survival 63.5% black vs. 85.5% white). Circulating plasma angiotensinogen levels were dysregulated (P < 0.001) only in black PN patients. Cutaneous transcriptomic analysis of genes related to the renin-angiotensin-aldosterone system (RAAS) revealed considerable dysregulation in PN lesions with greater dysregulation in black patients.CONCLUSIONS:
Significant dysregulation of the cutaneous and systemic RAAS in black PN patients may explain the increased incidence and severity of renal disease.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prurigo
/
Renin-Angiotensin System
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Dermatol Sci
Journal subject:
DERMATOLOGIA
Year:
2022
Type:
Article
Affiliation country:
United States