Heart Failure Subtypes and Cardiomyopathies in Women.
Circ Res
; 130(4): 436-454, 2022 02 18.
Article
in En
| MEDLINE
| ID: mdl-35175847
ABSTRACT
Heart failure affects over 2.6 million women and 3.4 million men in the United States with known sex differences in epidemiology, management, response to treatment, and outcomes across a wide spectrum of cardiomyopathies that include peripartum cardiomyopathy, hypertrophic cardiomyopathy, stress cardiomyopathy, cardiac amyloidosis, and sarcoidosis. Some of these sex-specific considerations are driven by the cellular effects of sex hormones on the renin-angiotensin-aldosterone system, endothelial response to injury, vascular aging, and left ventricular remodeling. Other sex differences are perpetuated by implicit bias leading to undertreatment and underrepresentation in clinical trials. The goal of this narrative review is to comprehensively examine the existing literature over the last decade regarding sex differences in various heart failure syndromes from pathophysiological insights to clinical practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sex Characteristics
/
Heart Failure
/
Cardiomyopathies
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Circ Res
Year:
2022
Type:
Article