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Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.
Huang, Han-Yi; Liao, Hsin-Yu; Chen, Xiaorui; Wang, Szu-Wen; Cheng, Cheng-Wei; Shahed-Al-Mahmud, Md; Liu, Yo-Min; Mohapatra, Arpita; Chen, Ting-Hua; Lo, Jennifer M; Wu, Yi-Min; Ma, Hsiu-Hua; Chang, Yi-Hsuan; Tsai, Ho-Yang; Chou, Yu-Chi; Hsueh, Yi-Ping; Tsai, Ching-Yen; Huang, Pau-Yi; Chang, Sui-Yuan; Chao, Tai-Ling; Kao, Han-Chieh; Tsai, Ya-Min; Chen, Yen-Hui; Wu, Chung-Yi; Jan, Jia-Tsrong; Cheng, Ting-Jen Rachel; Lin, Kuo-I; Ma, Che; Wong, Chi-Huey.
Affiliation
  • Huang HY; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Liao HY; GIP-TRIAD Master's Program in Agro-Biomedical Science, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
  • Chen X; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Wang SW; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Cheng CW; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Shahed-Al-Mahmud M; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
  • Liu YM; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Mohapatra A; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Chen TH; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Lo JM; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Wu YM; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Ma HH; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Chang YH; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
  • Tsai HY; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Chou YC; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Hsueh YP; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
  • Tsai CY; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Huang PY; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
  • Chang SY; Biomedical Translation Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Chao TL; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
  • Kao HC; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
  • Tsai YM; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
  • Chen YH; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
  • Wu CY; Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100233, Taiwan.
  • Jan JT; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
  • Cheng TR; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
  • Lin KI; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100233, Taiwan.
  • Ma C; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
  • Wong CH; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Sci Transl Med ; 14(639): eabm0899, 2022 04 06.
Article in En | MEDLINE | ID: mdl-35230146
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2022 Type: Article Affiliation country: Taiwan
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / Spike Glycoprotein, Coronavirus / COVID-19 Vaccines Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2022 Type: Article Affiliation country: Taiwan