CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.
Aging Cell
; 21(4): e13589, 2022 04.
Article
in En
| MEDLINE
| ID: mdl-35263032
ABSTRACT
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Longevity
/
NAD
Limits:
Animals
Language:
En
Journal:
Aging Cell
Year:
2022
Type:
Article
Affiliation country:
United States