Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC-MS/MS assay.

Zhang, Ying; Liu, Ya-Nan; Xie, Saili; Xu, Xuegu; Xu, Ren-Ai

Zhang, Ying; Liu, Ya-Nan; Xie, Saili; Xu, Xuegu; Xu, Ren-Ai.

Affiliation

Zhang Y; Department of Pharmacy, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, China.
Liu YN; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China.
Xie S; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xu X; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xu RA; The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Pharm Biol ; 60(1): 621-626, 2022 Dec.

Article in En | MEDLINE | ID: mdl-35289238

Subject(s)

Chromatography, High Pressure Liquid/methods; Oxazoles/pharmacokinetics; Pyridines/pharmacokinetics; Quercetin/pharmacology; Quinazolines/pharmacokinetics; Tandem Mass Spectrometry/methods; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/analysis; Antineoplastic Agents/pharmacokinetics; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Limit of Detection; Male; Oxazoles/administration & dosage; Oxazoles/analysis; Pyridines/administration & dosage; Pyridines/analysis; Quercetin/administration & dosage; Quinazolines/administration & dosage; Quinazolines/analysis; Rats; Rats, Sprague-Dawley

Key words

Drugdrug interaction; HER2-positive breast cancer; cancer treatment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Pyridines / Quercetin / Quinazolines / Chromatography, High Pressure Liquid / Tandem Mass Spectrometry Type of study: Prognostic_studies Limits: Animals Language: En Journal: Pharm Biol Year: 2022 Type: Article Affiliation country: China

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