Different organ and tissue tropism between Akabane virus genogroups in a mouse model.
Virus Res
; 314: 198752, 2022 06.
Article
in En
| MEDLINE
| ID: mdl-35331837
ABSTRACT
Akabane virus (AKAV) is an etiological agent that is teratogenic to the fetus of domestic ruminants, causing a significant loss of reproduction in livestock. In East Asia, AKAV isolates form two major clusters genogroups I and II. In recent years, genogroup I isolates have also been associated with postnatal encephalomyelitis, mainly in calves. Here, we compared the pathogenicity in mice using genogroup I Iriki and genogroup II OBE-1 strains. Only mice infected intraperitoneally with the Iriki strain died and showed marked replication in the central nervous system (CNS) and lymphoid tissues. A more elevated blood-brain barrier (BBB) permeability was found in the Iriki-infected mice in the clinical phase, indicating that the BBB might be a possible route of viral transmission from the periphery to the CNS. These findings demonstrate that the Iriki strain presents greater neurovirulence and neuroinvasiveness compared with the OBE-1 strain, determining different AKAV pathogenicity among genogroups.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Orthobunyavirus
/
Bunyaviridae Infections
/
Encephalomyelitis
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2022
Type:
Article