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Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi, Yun; Kerry, Philip S; Nanson, Jeffrey D; Bosanac, Todd; Sasaki, Yo; Krauss, Raul; Saikot, Forhad K; Adams, Sarah E; Mosaiab, Tamim; Masic, Veronika; Mao, Xianrong; Rose, Faith; Vasquez, Eduardo; Furrer, Marieke; Cunnea, Katie; Brearley, Andrew; Gu, Weixi; Luo, Zhenyao; Brillault, Lou; Landsberg, Michael J; DiAntonio, Aaron; Kobe, Bostjan; Milbrandt, Jeffrey; Hughes, Robert O; Ve, Thomas.
Affiliation
  • Shi Y; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
  • Kerry PS; Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.
  • Nanson JD; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia.
  • Bosanac T; Disarm Therapeutics, a wholly-owned subsidiary of Eli Lilly & Co., Cambridge, MA, USA.
  • Sasaki Y; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
  • Krauss R; Disarm Therapeutics, a wholly-owned subsidiary of Eli Lilly & Co., Cambridge, MA, USA.
  • Saikot FK; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia.
  • Adams SE; Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.
  • Mosaiab T; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
  • Masic V; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
  • Mao X; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
  • Rose F; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
  • Vasquez E; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
  • Furrer M; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany.
  • Cunnea K; Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.
  • Brearley A; Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.
  • Gu W; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia.
  • Luo Z; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia.
  • Brillault L; Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Australia.
  • Landsberg MJ; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia.
  • DiAntonio A; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Developmental Biology, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
  • Kobe B; School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, QLD 4072, Australia.
  • Milbrandt J; Needleman Center for Neurometabolism and Axonal Therapeutics and Department of Genetics, Washington University School of Medicine in Saint Louis, St. Louis, MO, USA.
  • Hughes RO; Disarm Therapeutics, a wholly-owned subsidiary of Eli Lilly & Co., Cambridge, MA, USA. Electronic address: rhughes@disarmtx.com.
  • Ve T; Institute for Glycomics, Griffith University, Southport, QLD 4222, Australia. Electronic address: t.ve@griffith.edu.au.
Mol Cell ; 82(9): 1643-1659.e10, 2022 05 05.
Article in En | MEDLINE | ID: mdl-35334231
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Armadillo Domain Proteins / NAD Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Armadillo Domain Proteins / NAD Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: Australia