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MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity.
Munasinghe, Thilini S; Edwards, Megan R; Tsimbalyuk, Sofiya; Vogel, Olivia A; Smith, Kate M; Stewart, Murray; Foster, Justin K; Bosence, Loretta A; Aragão, David; Roby, Justin A; Basler, Christopher F; Forwood, Jade K.
Affiliation
  • Munasinghe TS; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia.
  • Edwards MR; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.
  • Tsimbalyuk S; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia.
  • Vogel OA; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.
  • Smith KM; Paul Scherrer Institut, Swiss Light Source, 5232, Villigen PSI, Switzerland.
  • Stewart M; MRC Laboratory of Molecular Biology, Francis Crick Ave., Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.
  • Foster JK; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia.
  • Bosence LA; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia.
  • Aragão D; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
  • Roby JA; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia. jroby@csu.edu.au.
  • Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA. chris.basler@mssm.edu.
  • Forwood JK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. chris.basler@mssm.edu.
Nat Commun ; 13(1): 1604, 2022 03 25.
Article in En | MEDLINE | ID: mdl-35338144
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronavirus Infections / Middle East Respiratory Syndrome Coronavirus Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Type: Article Affiliation country: Australia