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Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.
Lee, J Y; Khaing, Z Z; Siegel, J J; Schmidt, C E.
Affiliation
  • Lee JY; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
  • Khaing ZZ; School of Materials Science and Engineering, Gwangju Institute of Science and Engineering, Gwangju, South Korea.
  • Siegel JJ; Department of Biomedical Engineering, The University of Florida at Gainesville, Gainesville, FL, USA.
  • Schmidt CE; Center for Learning and Memory, The University of Texas at Austin, Austin, TX, USA.
RSC Adv ; 5(49): 39228-39231, 2015.
Article in En | MEDLINE | ID: mdl-35528963
ABSTRACT
Surface of neural probes were electrochemically modified with a non-cell adhesive and biocompatible conjugate, pyrrole-hyaluronic acid (PyHA), to reduce reactive astrogliosis. Poly(PyHA)-modified wire electrodes were implanted into rat motor cortices for three weeks and were found to markedly reduce the expression of glial fibrillary acidic protein compared to uncoated electrodes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: RSC Adv Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: RSC Adv Year: 2015 Type: Article Affiliation country: United States