Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to <i>N</i>-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite.

Rashid, Md Harunur; Babu, Dinesh; Tran, Newton; Reiz, Béla; Siraki, Arno G

Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite.

Rashid, Md Harunur; Babu, Dinesh; Tran, Newton; Reiz, Béla; Siraki, Arno G.

Affiliation

Rashid MH; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Babu D; Institute of Food and Radiation Biology, Bangladesh Atomic Energy Commission, 1207 Dhaka, Bangladesh.
Tran N; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Reiz B; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Siraki AG; Department of Chemistry, Faculty of Sciences, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

Chem Res Toxicol ; 35(6): 1001-1010, 2022 06 20.

Article in En | MEDLINE | ID: mdl-35575633

Subject(s)

Clozapine; Clozapine/metabolism; Clozapine/pharmacology; Cytochrome P-450 Enzyme System/metabolism; Demethylation; Glutathione/metabolism; Humans; Hydrogen Peroxide; Neutrophils/metabolism; Peroxidase/metabolism; Quetiapine Fumarate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clozapine Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2022 Type: Article Affiliation country: Canada

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