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The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.
Schembs, Leah; Willems, Ariane; Hasenpusch-Theil, Kerstin; Cooper, James D; Whiting, Katie; Burr, Karen; Bøstrand, Sunniva M K; Selvaraj, Bhuvaneish T; Chandran, Siddharthan; Theil, Thomas.
Affiliation
  • Schembs L; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
  • Willems A; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9X
  • Hasenpusch-Theil K; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK.
  • Cooper JD; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Whiting K; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
  • Burr K; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Bøstrand SMK; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.
  • Selvaraj BT; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Chandran S; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9X
  • Theil T; Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK. Electronic address: thomas.theil@ed.ac.uk.
Cell Rep ; 39(7): 110811, 2022 05 17.
Article in En | MEDLINE | ID: mdl-35584663
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telencephalon / Cilia / Phosphoric Monoester Hydrolases / Hedgehog Proteins Limits: Humans Language: En Journal: Cell Rep Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telencephalon / Cilia / Phosphoric Monoester Hydrolases / Hedgehog Proteins Limits: Humans Language: En Journal: Cell Rep Year: 2022 Type: Article Affiliation country: United kingdom