Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation.

Zhang, Rong-Mo; Tiedemann, Kerstin; Muthu, Muthu L; Dinesh, Neha E H; Komarova, Svetlana; Ramkhelawon, Bhama; Reinhardt, Dieter P

Zhang, Rong-Mo; Tiedemann, Kerstin; Muthu, Muthu L; Dinesh, Neha E H; Komarova, Svetlana; Ramkhelawon, Bhama; Reinhardt, Dieter P.

Affiliation

Zhang RM; Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.
Tiedemann K; Shriners Hospital for Children-Canada, Montreal, Canada.
Muthu ML; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.
Dinesh NEH; Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.
Komarova S; Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada.
Ramkhelawon B; Shriners Hospital for Children-Canada, Montreal, Canada.
Reinhardt DP; Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.

Cell Mol Life Sci ; 79(6): 314, 2022 May 23.

Article in En | MEDLINE | ID: mdl-35606547

Subject(s)

Aortic Aneurysm, Thoracic; Marfan Syndrome; MicroRNAs; Animals; Aortic Aneurysm, Thoracic/genetics; Aortic Aneurysm, Thoracic/metabolism; Cytokines; Digoxin; Disease Models, Animal; Fibrillin-1/genetics; Fibrillin-1/metabolism; Humans; Hypoxia/genetics; Marfan Syndrome/complications; Marfan Syndrome/genetics; Matrix Metalloproteinase 12; MicroRNAs/genetics

Key words

Fibrillin-1 deficiency; Hypoxia; Inflammation; Matrix metalloproteinase; Thoracic aortic aneurysm; miR-122

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Aneurysm, Thoracic / MicroRNAs / Marfan Syndrome Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2022 Type: Article Affiliation country: Canada

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