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Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.
Bufton, Joshua C; Powers, Kyle T; Szeto, Jenn-Yeu A; Toelzer, Christine; Berger, Imre; Schaffitzel, Christiane.
Affiliation
  • Bufton JC; School of Biochemistry, University of Bristol; University Walk, Bristol BS8 1TD, UK.
  • Powers KT; School of Biochemistry, University of Bristol; University Walk, Bristol BS8 1TD, UK.
  • Szeto JA; School of Biochemistry, University of Bristol; University Walk, Bristol BS8 1TD, UK.
  • Toelzer C; School of Biochemistry, University of Bristol; University Walk, Bristol BS8 1TD, UK.
  • Berger I; School of Biochemistry, University of Bristol; University Walk, Bristol BS8 1TD, UK.
  • Schaffitzel C; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.
Nucleic Acids Res ; 50(10): 5934-5947, 2022 06 10.
Article in En | MEDLINE | ID: mdl-35640974
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nonsense Mediated mRNA Decay / Intellectual Disability Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2022 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nonsense Mediated mRNA Decay / Intellectual Disability Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2022 Type: Article Affiliation country: United kingdom