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Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.
Lopez, Seymour M; Aksman, Leon M; Oxtoby, Neil P; Vos, Sjoerd B; Rao, Jun; Kaestner, Erik; Alhusaini, Saud; Alvim, Marina; Bender, Benjamin; Bernasconi, Andrea; Bernasconi, Neda; Bernhardt, Boris; Bonilha, Leonardo; Caciagli, Lorenzo; Caldairou, Benoit; Caligiuri, Maria Eugenia; Calvet, Angels; Cendes, Fernando; Concha, Luis; Conde-Blanco, Estefania; Davoodi-Bojd, Esmaeil; de Bézenac, Christophe; Delanty, Norman; Desmond, Patricia M; Devinsky, Orrin; Domin, Martin; Duncan, John S; Focke, Niels K; Foley, Sonya; Fortunato, Francesco; Galovic, Marian; Gambardella, Antonio; Gleichgerrcht, Ezequiel; Guerrini, Renzo; Hamandi, Khalid; Ives-Deliperi, Victoria; Jackson, Graeme D; Jahanshad, Neda; Keller, Simon S; Kochunov, Peter; Kotikalapudi, Raviteja; Kreilkamp, Barbara A K; Labate, Angelo; Larivière, Sara; Lenge, Matteo; Lui, Elaine; Malpas, Charles; Martin, Pascal; Mascalchi, Mario; Medland, Sarah E.
Affiliation
  • Lopez SM; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
  • Aksman LM; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
  • Oxtoby NP; Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Vos SB; Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
  • Rao J; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
  • Kaestner E; Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Alhusaini S; Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
  • Alvim M; Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
  • Bender B; Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Bernasconi A; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Bernasconi N; Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.
  • Bernhardt B; Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
  • Bonilha L; Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
  • Caciagli L; Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
  • Caldairou B; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
  • Caligiuri ME; Department of Neurology, Emory University, Atlanta, USA.
  • Calvet A; Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
  • Cendes F; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Concha L; Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
  • Conde-Blanco E; Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Davoodi-Bojd E; Magnetic Resonance Image Core Facility, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain.
  • de Bézenac C; Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.
  • Delanty N; Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexico.
  • Desmond PM; Epilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spain.
  • Devinsky O; August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain.
  • Domin M; Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.
  • Duncan JS; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Focke NK; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Foley S; FutureNeuro SFI Research Centre for Rare and Chronic Neurological Diseases, Dublin, Ireland.
  • Fortunato F; Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
  • Galovic M; New York University Grossman School of Medicine, New York, New York, USA.
  • Gambardella A; Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, Greifswald University Medicine, Greifswald, Germany.
  • Gleichgerrcht E; Department of Neurology, Emory University, Atlanta, USA.
  • Guerrini R; Chalfont Centre for Epilepsy, Chalfont St Peter, UK.
  • Hamandi K; Department of Neurology, University Medical Center, Göttingen, Germany.
  • Ives-Deliperi V; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Jackson GD; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Jahanshad N; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Keller SS; Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
  • Kochunov P; Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Kotikalapudi R; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
  • Kreilkamp BAK; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
  • Labate A; Neuroscience Department, University of Florence, Florence, Italy.
  • Larivière S; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Lenge M; Wales Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.
  • Lui E; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Malpas C; Florey Institute of Neuroscience and Mental Health, Austin Campus, Heidelberg, Victoria, Australia.
  • Martin P; University of Melbourne, Parkville, Victoria, Australia.
  • Mascalchi M; Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.
  • Medland SE; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Epilepsia ; 63(8): 2081-2095, 2022 08.
Article in En | MEDLINE | ID: mdl-35656586
ABSTRACT

OBJECTIVE:

Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features.

METHODS:

We extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance.

RESULTS:

In MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10-16 ), age at onset (ρ = -.18, p = 9.82 × 10-7 ), and ASM resistance (area under the curve = .59, p = .043, Mann-Whitney U test). However, associations were driven by cases assigned to EBM Stage 0, which represents MTLE-HS with mild or nondetectable abnormality on T1W MRI.

SIGNIFICANCE:

From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsy / Epilepsy, Temporal Lobe Type of study: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Epilepsia Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsy / Epilepsy, Temporal Lobe Type of study: Clinical_trials / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Epilepsia Year: 2022 Type: Article Affiliation country: United kingdom