Hepatic lipase: a member of a family of structurally related lipases.
Biochim Biophys Acta
; 919(1): 13-20, 1987 May 13.
Article
in En
| MEDLINE
| ID: mdl-3567217
ABSTRACT
Partial amino acid sequence of rat hepatic lipase was obtained by gas-phase microsequence analysis of proteolytic fragments. Sequence comparison to bovine lipoprotein lipase and porcine pancreatic lipase reveals a highly conserved region existing among these three physiologically distinct lipolytic enzymes. In a stretch of 36 amino acid residues previously reported for pancreatic lipase (De Caro, J., Boudouard, M., Bonicel, J., Guidoni, A., Desnuelle, P. and Rovery, M. (1981) Biochim. Biophys. Acta 671, 129-138), nineteen residues are identical for all three enzymes, whereas 27 of 36 are identical in rat hepatic lipase and bovine lipoprotein lipase. The fact that this primary structural conservation extends to three different animal species emphasizes the conclusion that these lipolytic enzymes comprise a protein family originating from a common ancestral gene.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lipase
/
Liver
Limits:
Animals
Language:
En
Journal:
Biochim Biophys Acta
Year:
1987
Type:
Article