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Can Diffusion Tensor Imaging Apparent Diffusion Coefficient Diagnose Carpal Tunnel Syndrome? A Systematic Review and Meta-Analysis.
Evans, Adam G; Morgan, Maurice D; Aiken, Benjamin A; Assi, Patrick E; Joseph, Jeremy T; Kesayan, Tigran; Mioton, Lauren M; Esteve, Isaac V M; Hill, J Bradford; Thayer, Wesley P; Al Kassis, Salam.
Affiliation
  • Evans AG; Meharry Medical College, Nashville, TN, USA.
  • Morgan MD; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Aiken BA; Meharry Medical College, Nashville, TN, USA.
  • Assi PE; Meharry Medical College, Nashville, TN, USA.
  • Joseph JT; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Kesayan T; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mioton LM; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Esteve IVM; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Hill JB; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Thayer WP; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Al Kassis S; Vanderbilt University Medical Center, Nashville, TN, USA.
Hand (N Y) ; 18(1_suppl): 91S-99S, 2023 01.
Article in En | MEDLINE | ID: mdl-35695339
Magnetic resonance diffusion tensor imaging (DTI) can detect microstructural changes in peripheral nerves. Studies have reported that the median nerve apparent diffusion coefficient (ADC), a quantification of water molecule diffusion direction, is sensitive in diagnosing carpal tunnel syndrome (CTS). Five databases were searched for studies using ADC to investigate CTS. Apparent diffusion coefficient (measured in mm2/s) were pooled in random-effects meta-analyses. Twenty-two studies met criteria yielding 592 patients with CTS and 414 controls. Median nerve ADC were measured at the level of the distal radioulnar joint (CTS ADC: 1.11, 95% CI: 1.07-1.15, I2 = 54%; control ADC: 1.04, 95% CI: 1.01-1.07, I2 = 57%), pisiform (CTS ADC: 1.39, 95% CI: 1.37-1.42, I2 = 0%; control ADC: 1.27, 95% CI: 1.23-1.31, I2 = 59%), hamate (CTS ADC: 1.40, 95% CI: 1.36-1.43, I2 = 58%; control ADC: 1.27, 95% CI: 1.25-1.28, I2 = 47%), and as an combination of several measurements (CTS ADC: 1.40, 95% CI: 1.37-1.47, I2 = 100%; control ADC: 1.39, 95% CI: 1.24-1.53, I2 = 100%). Median nerve ADC is decreased in individuals with CTS compared to controls at the levels of the hamate and pisiform. ADC cut-offs to diagnose CTS should be established according to these anatomic levels and can be improved through additional studies that include use of a wrist coil.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carpal Tunnel Syndrome Type of study: Diagnostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Hand (N Y) Year: 2023 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carpal Tunnel Syndrome Type of study: Diagnostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Hand (N Y) Year: 2023 Type: Article Affiliation country: United States