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SPEAR: Systematic ProtEin AnnotatoR.
Crown, Matthew; Teruel, Natália; Najmanovich, Rafael; Bashton, Matthew.
Affiliation
  • Crown M; Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
  • Teruel N; Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC H3T 1J4, Canada.
  • Najmanovich R; Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC H3T 1J4, Canada.
  • Bashton M; Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Bioinformatics ; 38(15): 3827-3829, 2022 08 02.
Article in En | MEDLINE | ID: mdl-35695776
ABSTRACT

SUMMARY:

We present Systematic ProtEin AnnotatoR (SPEAR), a lightweight and rapid SARS-CoV-2 variant annotation and scoring tool, for identifying mutations contributing to potential immune escape and transmissibility (ACE2 binding) at point of sequencing. SPEAR can be used in the field to evaluate genomic surveillance results in real time and features a powerful interactive data visualization report. AVAILABILITY AND IMPLEMENTATION SPEAR and documentation are freely available on GitHub https//github.com/m-crown/SPEAR and are implemented in Python and installable via Conda environment. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioinformatics Journal subject: INFORMATICA MEDICA Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioinformatics Journal subject: INFORMATICA MEDICA Year: 2022 Type: Article Affiliation country: United kingdom