Local fitness and epistatic effects lead to distinct patterns of linkage disequilibrium in protein-coding genes.

Ragsdale, Aaron P

Ragsdale, Aaron P.

Affiliation

Ragsdale AP; Department of Integrative Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.

Genetics ; 221(4)2022 07 30.

Article in En | MEDLINE | ID: mdl-35736370

Subject(s)

Epistasis, Genetic; Models, Genetic; Biological Evolution; Gene Frequency; Humans; Linkage Disequilibrium; Selection, Genetic

Key words

diffusion approximation; distribution of fitness effects; epistasis; interference; linkage disequilibrium

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epistasis, Genetic / Models, Genetic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Genetics Year: 2022 Type: Article Affiliation country: United States

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