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Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome.
Niu, Wei-Xiao; Bao, Yun-Yang; Zhang, Na; Lu, Zhen-Ning; Ge, Mao-Xu; Li, Yi-Ming; Li, Yi; Chen, Ming-Hua; He, Hong-Wei.
Affiliation
  • Niu WX; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Bao YY; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Zhang N; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Lu ZN; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Ge MX; Department of Pharmacy, Qilu Hospital of Shandong University, Jinan 250012, China.
  • Li YM; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Li Y; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Chen MH; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: chenminghua@imb.pumc.edu.cn.
  • He HW; Key Laboratory of Biotechnology of Antibiotics, the National Health and Family Planning Commission (NHFPC), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: hehwei@imb.pumc.edu.cn.
Bioorg Chem ; 127: 105971, 2022 10.
Article in En | MEDLINE | ID: mdl-35749855
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / Non-alcoholic Fatty Liver Disease / Mevalonic Acid Limits: Animals / Humans Language: En Journal: Bioorg Chem Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / Non-alcoholic Fatty Liver Disease / Mevalonic Acid Limits: Animals / Humans Language: En Journal: Bioorg Chem Year: 2022 Type: Article Affiliation country: China