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Effect of the ADCC-Modulating Mutations and the Selection of Human IgG Isotypes on Physicochemical Properties of Fc.
Wu, Helen Haixia; Crames, Maureen; Wei, Yangjie; Liu, Dongmei; Gueneva-Boucheva, Kristina; Son, Ikbae; Frego, Lee; Han, Fei; Kroe-Barrett, Rachel; Nixon, Andrew; Marlow, Michael.
Affiliation
  • Wu HH; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA. Electronic address: helen.wu@boehringer-ingelheim.com.
  • Crames M; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Wei Y; Amgen Inc., Drug Product Technologies, Thousand Oaks, CA, USA.
  • Liu D; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Gueneva-Boucheva K; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Son I; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Frego L; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Han F; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Kroe-Barrett R; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Nixon A; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
  • Marlow M; Boehringer Ingelheim Pharmaceuticals Inc., Innovation Unit, Biotherapeutics Discovery, Ridgefield, CT, USA.
J Pharm Sci ; 111(9): 2411-2421, 2022 09.
Article in En | MEDLINE | ID: mdl-35760121
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, IgG / Antibody-Dependent Cell Cytotoxicity Limits: Humans Language: En Journal: J Pharm Sci Year: 2022 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, IgG / Antibody-Dependent Cell Cytotoxicity Limits: Humans Language: En Journal: J Pharm Sci Year: 2022 Type: Article