First Report of Thoracic Carcinoma With DEK::AFF2 Rearrangement: A Case Report.
J Thorac Oncol
; 17(8): 1050-1053, 2022 08.
Article
in En
| MEDLINE
| ID: mdl-35773081
ABSTRACT
DEKAFF2 carcinomas of the head and neck region have been recently described and reported to have aggressive clinical behavior but exceptional sensitivity to immunotherapy. We report a case of a 26-year-old female, never smoker, with a 5.2-cm left lower lobe central lung mass, with morphologic features identical to those reported for DEKAFF2 head and neck carcinomas, including mixed papillary exophytic and invasive components, squamous/basaloid features, and monomorphic cytomorphology. DEK (exon 7)AFF2 (exon 9) fusion was identified by whole-transcriptome RNA sequencing. This is the first report of thoracic DEKAFF2 carcinoma, indicating that these tumors are not confined to the head and neck region but can involve both upper and lower respiratory tracts. This entity should be considered in the differential diagnosis of squamous cell carcinomas in never smokers lacking other known oncogenic mutations.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thoracic Neoplasms
/
Carcinoma, Squamous Cell
/
Head and Neck Neoplasms
/
Lung Neoplasms
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Thorac Oncol
Year:
2022
Type:
Article