Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer.
Cell Biol Int
; 46(10): 1612-1624, 2022 Oct.
Article
in En
| MEDLINE
| ID: mdl-35819083
ABSTRACT
Biogenic synthesis of selenium nanoparticles (SeNPs) using plant extracts has emerged as a promising alternative approach to traditional chemical synthesis. The current study aims to introduce a safe, low-cost, and green synthesis of SeNPs using fresh fruit extract of Vaccinium arctostaphylos L. The biogenic synthesis of SeNPs was confirmed by different analyses including ultraviolet-visible spectrophotometry, Fourier transform infrared, and energy-dispersive X-ray. Also, the crystalline nature, size, and morphology of the obtained SeNPs were characterized by X-ray diffraction, dynamic light scattering, field emission scanning electron microscopy, and transmission electron microscopy techniques. The SeNPs were successfully synthesized with fruit extract of V. arctostaphylos L. in a regular spherical form and narrow size distribution with suitable zeta-potential values and exhibited appropriate biocompatibility. It revealed that the synthesized SeNPs can significantly inhibit the growth of 4T1 breast cancer cells with an IC50 of â¼84.19 ± 25.96 µg/ml after 72 h treatment. Overall, it can be concluded that the green synthesized SeNPs can be attractive, nontoxic, and eco-friendly candidates for drug delivery or medicinal applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selenium
/
Breast Neoplasms
/
Arctostaphylos
/
Vaccinium
/
Nanoparticles
/
Metal Nanoparticles
Limits:
Female
/
Humans
Language:
En
Journal:
Cell Biol Int
Year:
2022
Type:
Article
Affiliation country:
Iran